Michaelis-Menten Constraints Improved Cerebral Glucose Metabolism and Regional Lumped Constant Measurements with [18F]Fluorodeoxyglucose
نویسندگان
چکیده
منابع مشابه
Cerebral glucose uptake in humans at hypoglycemic plasma levels follows reversible Michaelis-Menten kinetics
Introduction Cerebral glucose levels in humans can be measured non-invasively by C MRS to determine the kinetics of glucose transport into the brain. This transport can be described by a reversible Michaelis-Menten (MM) model [1], which is characterized by a half-maximal transport constant (Kt) and maximal transport rate (Tmax) or maximal transport rate relative to CMRglc (Tmax/CMRglc). Several...
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Nearly 100 years ago Michaelis and Menten published their now classic paper [Michaelis, L., and Menten, M. L. (1913) Die Kinetik der Invertinwirkung. Biochem. Z. 49, 333-369] in which they showed that the rate of an enzyme-catalyzed reaction is proportional to the concentration of the enzyme-substrate complex predicted by the Michaelis-Menten equation. Because the original text was written in G...
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This paper summarizes our present theoretical understanding of single-molecule kinetics associated with the Michaelis-Menten mechanism of enzymatic reactions. Single-molecule enzymatic turnover experiments typically measure the probability density f(t) of the stochastic waiting time t for individual turnovers. While f(t) can be reconciled with ensemble kinetics, it contains more information tha...
متن کاملIn vivo measurements of brain glucose transport using the reversible Michaelis-Menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia.
Glucose is the major substrate that sustains normal brain function. When the brain glucose concentration approaches zero, glucose transport across the blood-brain barrier becomes rate limiting for metabolism during, for example, increased metabolic activity and hypoglycemia. Steady-state brain glucose concentrations in alpha-chloralose anesthetized rats were measured noninvasively as a function...
متن کاملThe Michaelis-Menten-Stueckelberg Theorem
We study chemical reactions with complex mechanisms under two assumptions: (i) intermediates are present in small amounts (this is the quasi-steady-state hypothesis or QSS) and (ii) they are in equilibrium relations with substrates (this is the quasiequilibrium hypothesis or QE). Under these assumptions, we prove the generalized mass action law together with the basic relations between kinetic ...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1990
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.1990.33